LIVER REGENERATION AND CHEMOTHERAPY, IS IT FEASIBLE?
نویسندگان
چکیده
Abstract Introduction Despite the known cytotoxic and hepatotoxic effects of most common chemotherapy drugs, their use in context liver regeneration as part antitumor treatment is controversial. Methods Thirty-six WAG/RijHsd rats were induced to selective portal ligation 50% hepatic parenchyma, divided into 3 experimental groups. 72 hours before, two groups treated with 5-Fluorouracil (50mg/kg) (5FU) or 5-FU + Oxaliplatin (10mg/kg) (5-FU+OX); third was untreated control. The weight animals remnant quantified biochemical profile determined after 24 (half animals) 7 days (the other half). Results did not show differences percentage 24h (control: 67±3.5; 5-FU: 66±2.9; 5-FU+OX: 65±1.1%). After hours, an increase AST ALT detected (5-FU 5-FU+OX) compared control (1783±110 vs. 2306±516 1400±273 IU/L; 1251 ±121 1822±386 949±145 IU/l, respectively, p<0.05). days, slight remained, but statistically significant. Albumin significantly altered throughout process, without normalizing days. Conclusion combined 5FU+OX does affect regenerated volume, although it triggers initial cytolytic reaction, which normalizes over time, nutritional deficit persisting.
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2023
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znac443.027